Cryo-EM structure of adenosine receptor A3AR bound to CF101
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8x16
Q-score: 0.31
Cai H, Guo S, Xu Y, Sun J, Li J, Xia Z, Jiang Y, Xie X, Xu HE
Nat Commun (2024) 15 pp. 3252-3252 [ Pubmed: 38627384 DOI: doi:10.1038/s41467-024-47207-6 ]
- Piclidenoson (510 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Bos taurus)
- Cryo-em structure of adenosine receptor a3ar bound to cf101 (160 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- G protein (Complex from Bos taurus)
- Scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Adenosine receptor a3 (36 kDa, Protein from Homo sapiens)
- G protein (Complex from Rattus norvegicus)
- A3ar (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
Cryo-EM structure of adenosine receptor A3AR bound to CF102
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8x17
Q-score: 0.473
Cai H, Guo S, Xu Y, Sun J, Li J, Xia Z, Jiang Y, Xie X, Xu HE
Nat Commun (2024) 15 pp. 3252-3252 [ Pubmed: 38627384 DOI: doi:10.1038/s41467-024-47207-6 ]
- Cryo-em structure of adenosine receptor a3ar bound to cf102 (160 kDa, Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- G protein (Complex from Bos taurus)
- A3ar (Complex from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Namodenoson (544 Da, Ligand)
- G protein (Complex from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Adenosine receptor a3 (36 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
Cryo-EM structure of SARS-CoV-2 Omicron BA.2 S-trimer in complex with fab L4.65 and L5.34
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8hp9
Q-score: 0.368
Guo S, Zheng Y, Gao Z, Duan M, Liu S, Du P, Xu X, Xu K, Zhao X, Chai Y, Wang P, Zhao Q, Gao GF, Dai L
Cell Discov (2023) 9 pp. 79-79 [ DOI: doi:10.1038/s41421-023-00585-5 Pubmed: 37507370 ]
- Spike protein s2' (125 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab l4.65 (23 kDa, Protein from Homo sapiens)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- Fab l4.65 (24 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 omicron ba.2 s-trimer in complex with fab l4.65 and l5.34 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 Omicron BA.4 S-trimer in complex with fab L4.65 and L5.34
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8hpq
Q-score: 0.243
Guo S, Zheng Y, Gao Z, Duan M, Liu S, Du P, Xu X, Xu K, Zhao X, Chai Y, Wang P, Zhao Q, Gao GF, Dai L
Cell Discov (2023) 9 pp. 79-79 [ DOI: doi:10.1038/s41421-023-00585-5 Pubmed: 37507370 ]
- Fab l4.65 (23 kDa, Protein from Homo sapiens)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- Fab l4.65 (24 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 omicron ba.4 s-trimer in complex with fab l4.65 and l5.34 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- Spike protein s2' (125 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 Omicron Prototype S-trimer in complex with fab L4.65 and L5.34
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8hpv
Q-score: 0.34
Guo S, Zheng Y, Gao Z, Duan M, Liu S, Du P, Xu X, Xu K, Zhao X, Chai Y, Wang P, Zhao Q, Gao GF, Dai L
Cell Discov (2023) 9 pp. 79-79 [ DOI: doi:10.1038/s41421-023-00585-5 Pubmed: 37507370 ]
- Fab l4.65 (23 kDa, Protein from Homo sapiens)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- Fab l4.65 (24 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 omicron prototype s-trimer in complex with fab l4.65 and l5.34 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- Spike protein s2' (125 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of SARS-CoV-2 Omicron BA.2 RBD in complex with fab L4.65 and L5.34
Resolution: 2.34 Å
EM Method: Single-particle
Fitted PDBs: 8hpf
Q-score: 0.494
Guo S, Zheng Y, Gao Z, Duan M, Liu S, Du P, Xu X, Xu K, Zhao X, Chai Y, Wang P, Zhao Q, Gao GF, Dai L
Cell Discov (2023) 9 pp. 79-79 [ DOI: doi:10.1038/s41421-023-00585-5 Pubmed: 37507370 ]
- Fab l4.65 (23 kDa, Protein from Homo sapiens)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 omicron ba.2 rbd in complex with fab l4.65 and l5.34 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab l4.65 (24 kDa, Protein from Homo sapiens)
- Spike protein s2' (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 Omicron BA.4 RBD in complex with fab L4.65 and L5.34
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8hpu
Q-score: 0.488
Guo S, Zheng Y, Gao Z, Duan M, Liu S, Du P, Xu X, Xu K, Zhao X, Chai Y, Wang P, Zhao Q, Gao GF, Dai L
Cell Discov (2023) 9 pp. 79-79 [ DOI: doi:10.1038/s41421-023-00585-5 Pubmed: 37507370 ]
- Fab l4.65 (23 kDa, Protein from Homo sapiens)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- Fab l4.65 (24 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 omicron ba.4 rbd in complex with fab l4.65 and l5.34 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- Spike protein s2' (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 Omicron Prototype RBD in complex with fab L4.65 and L5.34
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8hq7
Q-score: 0.528
Guo S, Zheng Y, Gao Z, Duan M, Liu S, Du P, Xu X, Xu K, Zhao X, Chai Y, Wang P, Zhao Q, Gao GF, Dai L
Cell Discov (2023) 9 pp. 79-79 [ DOI: doi:10.1038/s41421-023-00585-5 Pubmed: 37507370 ]
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab l4.65 (23 kDa, Protein from Homo sapiens)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 omicron prototype rbd in complex with fab l4.65 and l5.34 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab l4.65 (24 kDa, Protein from Homo sapiens)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
T1AM-bound mTAAR1-Gs protein complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8jlj
Q-score: 0.543
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- T1am-bound htaar1 (Complex from Mus musculus)
- Soluble cytochrome b562,trace amine-associated receptor 1 (50 kDa, Protein from Mus musculus)
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Mgs (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol (355 Da, Ligand)
Ulotaront(SEP-363856)-bound mTAAR1-Gs protein complex
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8jlk
Q-score: 0.387
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- T1am-bound htaar1 (Complex from Mus musculus)
- Soluble cytochrome b562,trace amine-associated receptor 1 (50 kDa, Protein from Mus musculus)
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Mgs (41 kDa, Protein from Homo sapiens)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)